Learning & education: Agmatine sulfate
Agmatine is a naturally occurring biogenic amine produced by decarboxylation of the amino acid arginine via the enzyme arginine decarboxylase. Its multifaceted neurochemical effects have positioned it as a potential modulator of mood and anxiety symptoms, though many questions remain about its clinical utility.
This article explores the biology, proposed mechanisms, the human and preclinical evidence behind agmatine sulfate with respect to neuropathic pain, typical doses used in published work, safety signals, and practical considerations for clinicians and patients.
This article looks to summarize the evidence on agmatine sulfate's mechanisms and potential benefits, known and possible side effects, practical dosing ranges used in studies and commercial supplements, as well as safety considerations.