GABA Supplements
GABA is an neurotransmitter that decreases the firing of neurons in the brain, relaxing and chilling out your brain (and you). But there is a paradox and a problem.
The paradox? You have to get excited before you can chill out. This is because GABA is made in the brain from glutamate, our primary excitatory neurotransmitter.
The problem? Despite what your GABA supplements may tell you, GABA itself can’t get across the blood- brain barrier (BBB) to work its magic.
Table of Contents
1. Do GABA Supplements Work? A Critical View
2. A GABA Alternative for Anxiousness and Stress: Tro Calm
3. A GABA Alternative for Sleep: Tro Zzz
6. Why our Buccal Troches are the Best GABA Supplement Alternatives
7. GABA Benefits and Side Effects
Several drugs mimic or increase GABA in the brain, including benzodiazepines and gabapentin, but taking GABA directly as a supplement won’t work for most people. This is because GABA is made in the brain and cannot easily get across the blood-brain barrier (BBB) when taken directly, despite what your supplement company may tell you.
Remember the “problem” above? Well, this is it! Another problem is that most of these pharmaceutical drugs that modulate GABA receptors are highly addictive and/or can induce tolerance and withdrawal when you stop them. But there’s good news! Much safer solutions are available, including N-nicotinoyl-GABA and Kava, which enhance GABA in novel ways (more below!).
Dr. Scott Sherr
A GABA Alternative for Anxiousness and Stress: Tro Calm
Tro Calm is our precision-dosed, pharmaceutical-grade, and physician-formulated buccal troche that will help you take the edge off, chill out, and quiet your mind. It has two ingredients that modulate the brain’s GABAergic system:
- N-nicotinoyl-GABA, a vitamin B3 attached to a GABA molecule, easily crosses the BBB and increases GABA directly. This is called orthosteric modulation of the GABA receptor.
- Kava binds to the GABA receptor at a separate site (allosteric modulation) and increases the binding of GABA.
When used as directed, these ingredients work synergistically and safely at low doses without risk of dependence or tolerance. Tro Calm also contains CBD and CBG, which modulate the GABergic and endocannabinoid systems.
The result of this novel formula? 1⁄4 troche will take the edge off and you’ll perform better, 1⁄2 troche and you’ll be more chill (think a glass or two of wine without the downside), 3⁄4 to 1 full troche for full relaxation, full quieting of the mind, and deeper sleep.
A GABA Alternative for Sleep: Tro Zzz
If sleep is what you're after, Tro Zzz offers a comprehensive approach to enhancing sleep quality. Unlike traditional GABA supplements that may struggle with efficient absorption and crossing the blood- brain barrier, Tro Zzz's formulation contains several ingredients that enhance the GABA system, including honokiol from magnolia bark and agarin, from the fly agaric mushroom. These two compounds easily cross the blood- brain barrier and work synergistically, supporting your natural sleep cycles.
With Tro Zzz, you will fall asleep faster, enjoy a deeper sleep for longer periods, and effortlessly returning to sleep if you wake during the night. It is an effective alternative to ordinary GABA supplements, providing a direct, efficient path to improved sleep induction and maintenance.
Learn more about Tro Zzz here and how it can help you wake up feeling rejuvenated and ready to conquer your day.
Why our Buccal Troches are the Best GABA Supplement Alternatives
While it's well-understood that many GABA supplements struggle to cross the blood-brain barrier (BBB) effectively, a solution stands out. Discover the advantages of Buccal Troches which contain novel ingredients which enhance the GABA system via orthosteric and allosteric compounds.
Let us explain...
Orthosteric compounds bind directly to the GABA site on the GABA receptor. Nicotinoyl-GABA (Tro Calm) and Agarin (Tro Zz) both do this. Allosteric compounds bind to a separate site on the GABA receptor, enhancing GABA binding. In Tro Calm, Kava, CBD, and CBG perform this role. In Tro Zzz, there is honokiol, CBD, and CBN make the GABA magic happen.
There is no other company on the planet has discovered the power of this combination!
Personalized Dosing
Every person is unique, and so is their optimal dose of GABA. We recognize this individuality, which is why our troches is scored. This design makes it effortless for users to split the troche and customize their dosage based on personal preference and response.
Buccal troche delivery
Have you been swallowing your supplements up until now? At Troscriptions, we do things a little differently - we use buccal troches.
A buccal troche is a uniquely designed delivery system that enhances the absorption of active ingredients directly into your bloodstream. Traditional methods (like tablets or powders) must navigate the detours of your digestive system, but buccal troches allow for more rapid and
effective absorption by skipping the digestive system. The result? A swift, potent effect for maximum benefits.
Note that it is also okay to swallow our buccal troches, however, if swallowed, your dose may need to increase to get the same effect.
Beyond USP Ingredients
USP designates a pharmaceutical grade ingredient but for some this may not be enough and there can still be contaminants. This is why at Troscriptions, we go above and Beyond USP. Every ingredient undergoes additional rigorous testing for heavy metals, purity, and potency giving you with peace of mind. Experience the Troscriptions difference, where premium quality and safety are our unwavering commitment to you.
Child-resistant packaging
Your safety and your family's safety is our top priority, which is why we've gone an extra mile to utilize child-resistant packaging for our products. We understand that this might make the packaging slightly more challenging to open, but it's a measure designed with the utmost safety in mind.
GABA Benefits and Side Effects
GABA supplements have been explored for their potential to support mental and physical health by promoting relaxation, improving sleep, and reducing anxiety. However, users should be aware of possible side effects, which can range from mild digestive issues to more pronounced drowsiness or muscle weakness. It's crucial to consider these factors when deciding to use GABA supplements as part of a wellness or healing regimen
Our Conclusion on GABA Supplements
Given the limitations associated with traditional GABA supplements, particularly their difficulty in crossing the blood-brain barrier effectively, buccal troches emerge as a superior alternative, especially when they contain allosteric and orthosteric compounds that enhance GABA.
Buccal troches allow direct absorption into the bloodstream, bypassing the digestive system and enhancing bioavailability. This delivery method not only maximizes the potential benefits of GABA without the common side effects associated with oral supplements but also offers a more efficient and user-friendly approach to leveraging the calming effects of GABA.
Frequently Asked Questions
GABA works by binding to GABA receptors in the brain, inhibiting neural activity, which can lead to decreased anxiety, enhanced mood, better sleep, and a feeling of calm. Supplements that increase GABA are a great option for those looking to naturally manage stress and anxiety levels. But remember: GABA itself doesn’t cross the blood- brain barrier. Tro Calm and Tro Zzz have proven ingredients that enhance the GABA system in novel ways, easily crossing the blood-brain barrier.
Supplements that increase GABA have effects that last several hours, with variability depending on individual metabolism and the specific GABA supplement dosage. Most users feel improvements within 4 to 6 hours after ingestion. Remember that most direct GABA supplementation wil have no or little effect.
There is no significant evidence indicating that supplements that increase GABA directly cause liver damage when taken at recommended doses. However, please consult your healthcare provider before starting/stopping any supplements or medications.
GABA's ability to cross the blood-brain barrier is limited, raising questions about the effectiveness of some GABA supplements for anxiety, stress, sleep, or any other purported benefit. This has led to the exploration of compounds that increase GABA indirectly, such as Kava (in Tro Calm) Honokiol, and Agarain (in Tro Zzz).
Regularly taking supplements that increase GABA or having foods that contain GABA is considered safe for most people, especially when following the recommended supplement dosage. Consistent use may lead to sustained benefits for managing stress and enhancing sleep quality.
The primary downside to taking supplements that increase GABA might include potential side effects such as drowsiness, digestive discomfort, headaches, and lowering of blood pressure. Furthermore, the challenge of crossing the blood-brain barrier will affect the efficacy of direct GABA supplemenation.
GABA taken directly will unlikely have a major effect as GABA does not cross the blood-brain barrier. However, ingredients in Tro Calm were designed to be relaxing and not sedating, using several ingredients that enhance GABA in novel ways. Tro Zzz contains GABA-enhancing ingredients that will make you sleep...that's why it is for sleep!
More about Troscriptions
Troscriptions, founded by Dr. Ted and his team of seasoned physicians, stands at the forefront of health optimization through their innovative use of buccal troches. With a foundation rooted in science-backed, pharmaceutical-grade formulas, Troscriptions leverages unparalleled expertise and a comprehensive understanding of health optimization, as defined by the absence of disease, balanced metabolic states, and life cycle awareness.
Learn more about Troscriptions and their commitment to treat and transcend traditional wellness boundaries, making them a trusted ally in your health optimization journey.
AI-generated responses are for informational purposes only and do not constitute medical advice. Accuracy, completeness, or timeliness are not guaranteed. Use at your own risk.
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