I have used TroCalm many times now, during different times of the day and for different purposes. I can use a small amount during the day, and reduce feelings of stress. I can use a medium amount, in the evening, and begin to wind down. I've also tried a full troche, at bedtime, and have slept very well, compared to nights when I haven't used this product. I've experienced no noticeable side effects from TroCalm, other than the odd taste. With that said, the packaging is beyond annoying! I despise this packaging, and have often been climbing around on the floor, searching for a quarter of a troche that has flown out of the package. I can't believe that this is the best they could do, from a packaging standpoint.