First-pass metabolism, otherwise known as the ‘first-pass effect’. This phenomenon relates mainly to drugs and other supplements that are consumed orally. The concentration of a drug or supplement that we ingest is often not the amount that is eventually seen in the blood (systemic circulation).
How well do you methylate? Where do these methyl groups come from? And why should you care? Well, Tro Nation, today’s article explores methylation in detail because, like Hansel from Zoolander, methylation is just “so hot right now”.
Get out your eggs! In this article, we will explore an important neurotransmitter in the body and brain called acetylcholine (ACh). While also functioning as a classical neuromodulator, ACh is similar to norepinephrine, serotonin, and dopamine, in that it cannot cross the blood-brain barrier.
In today’s article, we are going to cover the “fight or flight” (or “oh sh*t there’s a bear”) catecholamine and neurotransmitter known as norepinephrine (NE). As with gamma-aminobutyric acid (or GABA), serotonin, and dopamine, norepinephrine can’t cross the blood-brain barrier.
In today’s article, we are going to explore the well-known, indispensable, and now kind of infamous neurotransmitter dopamine. As with gamma-aminobutyric acid (or GABA) and serotonin, dopamine can’t cross the blood-brain barrier.
Before starting Troscriptions in 2019, we did a huge amount of research into the history of nootropics, the many varieties out there, and we tried many (many!) along the way. Although our brains usually enjoyed the ride (with some notably terrible exceptions), it became clear that no one could agree what a nootropic really was and what it wasn’t.
In today’s article, we are going to explore one of the most well-known and important neurotransmitters – serotonin. As with gamma-aminobutyric acid, or GABA, serotonin can’t cross the blood-brain barrier to do its work.