Cannabis has historically been used for a wide range of purposes, such as industrial, ornamental, and pharmaceutical applications [1,2]. In the modern world, marijuana use is permitted in some jurisdictions to help address the nausea caused by chemotherapy, anorexia in patients with AIDS, and to manage pain. It is also used recreationally to treat anxiety, insomnia, to stimulate an appetite, to simply get “high,” and much more.
Nowadays, cannabis is a popular topic in the news and on social media. You may have come across articles or blogs discussing compounds called cannabinoids that are present in cannabis plant and their effects on the neurotransmitter GABA. In this article, you’ll learn more about cannabinoids and their effects on mental health, especially in relation to the GABA system.
First-pass metabolism, otherwise known as the "first-pass effect." This phenomenon relates mainly to drugs and other supplements that are consumed orally. The concentration of a drug or supplement that we ingest is often not the amount that is eventually seen in the blood (systemic circulation).
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