First-pass metabolism, otherwise known as the ‘first-pass effect’. This phenomenon relates mainly to drugs and other supplements that are consumed orally. The concentration of a drug or supplement that we ingest is often not the amount that is eventually seen in the blood (systemic circulation).
In today’s article, we are going to explore the well-known, indispensable, and now kind of infamous neurotransmitter dopamine. As with gamma-aminobutyric acid (or GABA) and serotonin, dopamine can’t cross the blood-brain barrier.
Before starting Troscriptions in 2019, we did a huge amount of research into the history of nootropics, the many varieties out there, and we tried many (many!) along the way. Although our brains usually enjoyed the ride (with some notably terrible exceptions), it became clear that no one could agree what a nootropic really was and what it wasn’t.
In today’s article, we are going to explore one of the most well-known and important neurotransmitters – serotonin. As with gamma-aminobutyric acid, or GABA, serotonin can’t cross the blood-brain barrier to do its work.
CBD is certainly no longer the new kid on the block. In the last five years, it has exploded on the market in products that range from shampoos, skin creams, tinctures, suppositories, and (well, we’re sure you guessed it) troches of course! Why is CBD use so widespread?
A buccal troches is a small lozenge that dissolves between your upper cheek and gums. You don’t suck them. You don’t swallow them. And they are very effective.
Methylene Blue is one of the most fascinating compounds in the world. Originally, this article was featured on Dave Asprey’s Biohacked blog, but we've expanded and added more information.