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Meet Your Troscription (Tx)

Ingredients

Methylene Blue USP: 5 mg

Nicotine USP: 1 mg

Caffeine: 50 mg

CBD: 5 mg

Why Use Blue Cannatine

1. Focus

2. Productivity

3. Verbal Fluidity

4. Exercise Performance

5. Crush Jet Lag

6. Balance/ Coordination

Potential Interactions

SSRI and SNRI medications
Stimulant medications
Full list are linked below (per ingredient)

Contraindications

Pregnant or Breastfeeding
Not fit to take stimulants (sever cardiopulmonary disease)
Hepatic or renal impairment
Any known sensitivity to methylene blue or thiazine dyes, nicotine, caffeine, or CBD

Possible Side Effects

Blue urine: Methylene Blue concentrates in the urine. This is benign side effect.
Blue tongue/ teeth: Also benign, last 4 to 6 hours. Here are some remedies to help it go away faster if needed. Do NOT use if plastic veneers in place. Consult a dentist for any concerns
Stimulant-related: headache, nausea, dizziness, heart racing, GI distress, etc. These are rare if starting at a low dose and titrating to optimal dose.
Numbness/ tingling of tongue or cheek: due to peppermint in the formula. If it occurs, troches can be swallowed on an empty stomach.

Mechanism of Action

1. Methylene Blue

See full information with references here (article) and here (PDR):

A. Mitochondria:

• Increases ATP production (donates electrons to complex IV on ETC)

• Increases antioxidant reserve (accepts electrons to neutralize ROS)

• Increases NAD+ production via enhanced glycolysis and NADPH oxidation.

B. Mild MAOI ➔ Increases serotonin, dopamine, and norepinephrine.

C. Benefits include enhanced energy, neuroprotection, endurance, mood boosting

2. Nicotine

See full information with references here (article) and here (PDR):

A. Binds to nicotinic acetylcholine receptors, increasing dopamine, norepinephrine, and acetylcholine release.

B. Low-dose nicotine is well-studied in MCI and Alzheimer's. It is safe when not smoked or vaped and a total daily dose of <4 mg

C. Benefits include enhanced focus and concentration, verbal fluidity, memory, learning, neuroprotection.

D. Blue Cannatine uses just 1 mg of Nicotine in full troche (vs. 6 to 26 mg of Nicotine per cigarette and more in vaping products)

3. Caffeine

See full information with references here and here

A. Binds to adenosine receptors in the central and peripheral nervous systems, along with various other organs.

B. By binding to adenosine receptors, caffeine blocks adenosine from binding to A1 and A2A receptors (adenosine binding to these receptors promotes sleepiness and in A2A's case, blocks the release of dopamine.

C. Benefits include enhanced attention and alertness, reaction speed and accuracy, coordination and judgment, strength and endurance, memory.

D. There is 1/4 cup of coffee equivalent caffeine in a full Blue Cannatine troche

4. CBD

See full information and references here and here

A. Prevents the breakdown of FAAH (Fatty Acid Amine Hydrolase), an enzyme that breaks down Anandamide. B. Anandamide binds to CB1 and CB2 receptors, it sends a message to calm down the firing neurons that stimulate its release in a process called retrograde signaling.

C. Blocks equilibrative nucleoside transport (ENT) leading to the direct enhancement of adenosine A1 receptors.

D. Activates the nuclear peroxisome proliferator-activated-receptor- (PPAR), a transcription factor that governs the expression of genes involved in inflammation, redox equilibrium, insulin sensitivity, and the metabolism of lipids and glucose.

E. Benefits include: Reducing inflammation and pain, decreasing anxiety, decreasing nausea and vomiting, protecting the brain (neuroprotective).

How to Get Started with Blue Cannatine

Start dose of 1/4 to 1/2 troche Maximum daily dose: 4 troches per day Adults > 21 years of age or as directed by a healthcare practitioner.

If troche is swallowed, the dose may need to increase for desired effect.

Personalized Dosing

Every person is unique, and so is their optimal dose. We recognize this individuality, which is why each of our troches is scored. This design makes it effortless for users to split the troche and customize their dosage based on personal preference and response. The average launching dose for Blue Cannatine is ½ troche. There are 4 troches in each pack, and up to 16 servings.