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Meet Your Troscription (Tx)

Ingredients

CBD: 10 mg

Kava Kava: 100 mg (30% Kavalactones)

B3-GABA: 50 mg

CBG: 2 mg

Why Use Tro Calm

1. Decreasing stress and anxiousness

2. Performance anxiety (boardroom to bedroom)

3. Ruminating thoughts (Tro Calm quiets the mind)

4. Performance enhancement under stressful conditions

Potential Interactions

1. Do not combine with other GABAergic drugs unless under the supervision of a healthcare practitioner.

2. Do not use alcohol with Tro Calm.

3. Full list are linked below (per ingredient).

Contraindications

1. Pregnant and Breastfeeding

2. Hepatic or renal impairment

3. Operating any heavy machinery

Possible Side Effects

1. Orange tongue/teeth: due to annatto. This is a benign and short-lasting

2. Mild mouth numbness/ tingling:This is due to the Kava. It will resolve within 30 minutes.

3. Fatigue

4. In rare cases, some users may have a paradoxical effect due to the B3 in the formula and feel more activated and focused.

Mechanism of Action

1. CBG

See full information and references here and here

A. PPAR-gamma agonist. This particular PPAR transcription factor causes insulinsensitization and enhances glucose metabolism

B. Agonist of the alpha-2-adrenoreceptor which may mean that it has utility as an

anti-hypertensive, sedative, and pain reliever

C. Interacts with TRP receptors, a class of receptors that regulates temperature.

D. Potent antagonist (blocker) of the 5HT1A Serotonin receptor.

E. Benefits include: Neuroprotection, Decreased inflammation, Pain relief, Relaxation, Anticancer, Antibacterial, Glaucoma

2. B3 GABA (Nicotinyol GABA)

See full information and references here and here

A. Highly blood-brain barrier permeable due to the B3/Nicotinoyl group

B. When it crosses the blood-brain barrier, it hydrolyzes into niacin and GABA

C. GABA is the most abundant inhibitory neurotransmitter in the brain

D. Niacin vasodilates, increases NAD (which is vital for energy production), prevents neuronal apoptosis (programmed cell death), and plays a significant role in neuronal development.

E. Benefits include: Decreased anxiousness, Improved sleep quality, Neuroprotective

3. Kava Kava

See full information and references here and here

A. A selective positive allosteric modulator of the GABA receptor, increasing circulating GABA in the brain

B. It is a reversible MAO-B inhibitor, increasing dopamine and other neurotransmitters in the brain.

C. Inhibits both COX1 and COX2 enzymes which in turn reduce the production of prostaglandins, a class of chemicals that promote inflammation, pain, and fever.

D. Benefits include: Decreased anxiousness, Improved sleep quality, Neuroprotection, Decreased inflammation

4. CBD

See full information and references here (article):

A. Prevents the breakdown of FAAH (Fatty Acid Amine Hydrolase), an enzyme that
breaks down Anandamide.

B. Anandamide binds to CB1 and CB2 receptors, it sends a message to calm down
the firing neurons that stimulate its release in a process called retrograde
signaling.

C. Blocks equilibrative nucleoside transport (ENT) leading to the direct
enhancement of adenosine A1 receptors.

D. Activates the nuclear peroxisome proliferator-activated-receptor- (PPAR), a
transcription factor that governs the expression of genes involved in inflammation,
redox equilibrium, insulin sensitivity, and the metabolism of lipids and glucose.

E. Benefits include: Reducing inflammation and pain, decreasing anxiety, decreasing nausea and vomiting, protecting the brain (neuroprotective).

How to Get Started with Tro Calm

Start dose of 1/4 to 1/2 troche

Maximum daily dose: 4 troches per day

Typical response:

1/4 dose: Take the edge off, perform better

1/2 dose: Relax more, less focus

3/4 to full troche: Fully relax

If troche is swallowed, the dose may need to increase for desired effect.

Personalized Dosing

Every person is unique, and so is their optimal dose. We recognize this individuality, which is why each of our troches is scored. This design makes it effortless for users to split the troche and customize their dosage based on personal preference and response. Here’s a breakdown of our Tro Calm dosing…

¼ Troche: Take the edge off and perform better in everything you do.

½ Troche: The relaxing feeling of 1 to 2 glasses of alcohol.

¾ Troche: Chill out

1 Full Troche: Really chill out and increase deep sleep too!