1. Pregnant or Breastfeeding
2. Hepatic or renal impairment
3. Operating any heavy machinery
   
   

1. Mild mouth numbness/ tingling: This is due to the Kava. It will resolve within 30 minutes.
2. Fatigue
3. In rare cases, some users may have a paradoxical effect due to the B3 in the formula and feel more activated and focused.
   
   

Kavain: see full reference article here

• Most potent kavalactone of the Kava plant 
• Positive allosteric modulator of the GABA receptor, increasing affinity for GABA to bind
• ½ life = 1 hour
• Benefits: are due parasympathetic activation:

1. Rest/ relax
2. Digest
3. Detoxify
4. Sleep
5. Build muscle/protein synthesis
6. Decrease inflammation

Agarin: See full blog article here

• Long-acting orthosteric liand of the GABA-A receptor (½ life about 6 hours)
• Found in the Fly Agaric Mushroom (_Amanita muscaria_).
• Crosses the Blood Brain Barrier (unlike GABA itself)

Niacin: see full reference here

• A Form of Vitamin B3 that easily crosses the BBB.
• It’s Primary role: to act as a precursor for NAD⁺ and NADP⁺, the essential coenzymes in cellular redox reaction
• Enhanced neurotransmitter synthesis and metabolism (dopamine, serotonin, norepinephrine
• Neuroprotection and DNA repair
• ½ life = 1 hour
• Benefits include:

1. Increases energy via NAD+ (this is why Tro+ Calm is not typically sedating)
2. Mood boosting
3. Decrease inflammation