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See our blog articles for a deep dive into the science of all ingredients in Blue Cannatine.

Methylene Blue

Nicotine

Caffeine

CBD

If used as a buccal troche, yes. The rate of discoloration varies between 2 to 24 hours.

Warning: In addition to being a star ingredient, methylene blue is a dye. It will temporarily stain your mouth (including your teeth). If you have any concerns about dental work and/or prolonged staining, please consult your dentist. Blue tongue resolution speed will depend on how much you move it around when it is dissolving and the amount you use. There is no quick antidote but if you want to reduce the blue faster we have included tips below.

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When methylene blue is reduced, it decolorizes. Reducing agents such as sodium bicarbonate — add 1/4 tsp baking soda in 4 fl oz water and rinse the mouth with it for a few minutes — should reduce the methylene blue. This should be done ideally 5-10 minutes after the troche has fully dissolved. Since the reaction is acid-catalyzed, rinse the mouth with 1 part vinegar, and 1 part water first, right before rinsing with baking soda, which would hasten the decolorizing reaction. We also find that hot liquids help as well!

Polyethylene Glycol is a long-established FDA-approved drug delivery method used around the world, especially by compounding pharmacists. Do not confuse polyethylene glycol with propylene glycol. The latter is antifreeze and will kill you if you drink it…so please don’t do that!

Our formulations use polyethylene glycol that is both non-absorbable and very low dose, meaning that it does not get absorbed into your body and it will not cause GI distress or any of those other symptoms/issues that you may have heard about.

For more information, please see this article for an in-depth explanation.

There are 4 whole troches in each package and each troche can be cut into four quarters. Therefore, one pack can yield up to 16 doses, depending on your personalized needs. The troches are scored for easy titration.

Start with 1/4 troche to 1/2 troche and increase the dosage until you reach your optimal dose.

DO NOT exceed more than 4 whole troches in a 24-hour period.

For Tro+ Blue, the above instructions may not apply. Please follow the directions from your healthcare provider.

If it is not safe for you to use stimulants due to any medical condition, please do not use this product.

Do not use methylene blue if you are pregnant, breastfeeding, or have G6PD deficiency.

To avoid the risk of serotonin syndrome, do not use methylene blue if you are taking serotonergic drugs such as selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRI), or monoamine oxidase inhibitors (MAOi) unless directed by your healthcare practitioner.

There is also a potential risk for serotonin syndrome when methylene blue is used in combination with “psychedelics” that block serotonin reuptake therefore one should avoid this combination.