Starting from the very beginning of our existence, the process of aging initiates. It involves the deterioration of cellular structures, gene regulation, and DNA sequences, leading to the aging of individual cells and entire organisms. It is estimated that by 2050, the number of people aged over 80 will triple globally .
More than a decade ago, a pathbreaking discovery showed for the first time that mature mouse somatic cells could be reprogrammed into pluripotent stem cells (i.e., make them young again). The discovery was made by using the forced expression of four transcription factors: Oct4, Sox2, Klf4, and c-Myc.
These results came from the research group of Shinya Yamanaka, and hence these factors responsible for reprogramming induced pluripotent stem cells (iPSC) are called the Yamanaka factors .
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