Dendrites are the most essential part of synaptic formation; hence, forming new dendrites is critical for healthy brain functioning. Here are some ways to enhance it:
Chronic stress is one of the main causative agents of depression [18]. Scientists have shown that there is an adverse impact on the shape, activity, and function of dendrites, as well as on synaptic plasticity and the secretion of stress hormones (cortisol) due to chronic stress [7,12]. It is crucial to prevent chronic stress to preserve optimal neural and synaptic functioning. Studies have shown many positive effects of meditation on reducing chronic stress [28,29].
Studies have shown that sleep after motor learning activates the dendritogenesis and spinogenesis of postsynaptic dendrites [21,22]. Sleep also prevents the elimination of newly formed spines after learning multiple tasks [21,22]. Non-rapid eye movement sleep reactivates neurons are activated during motor tasks. Altering this hinders branch-specific dendritic spine formation [21,22].
Studies have found that a diet rich in antioxidants reduces dendritic spine loss [31]. Antioxidants eliminate reactive oxygen species (ROS) and protect the brain. Omega fatty acids have been shown to improve neuronal function mediated by the formation of new neurons and synapses [31,32]. Omega fatty acids also increase the secretion of neurotrophins like BDNF, NGF, NT-3, and NT-4, activating dendritogenesis [12,33,34].
Methylene Blue (MB) has been shown to activate the expression of PTEN-induced kinase 1 (PINK1) [35,36]. PINK1 is actively involved in regulating dendritic morphology [37]. Thus, the application of MB may positively impact dendritogenesis [38]. MB also activates BDNF [39,40], which has been shown to play an active role in dendritogenesis. MB enhances antioxidants in the body, which reduces ROS and improves cognitive function[35,38]. You can grab some now.
Neurobics (neuron+ aerobics) is a concept introduced by Dr. Lawrence Katz [41]. He developed a variety of brain exercises that can provide more oxygen to neurons and help improve cognitive function [41]. The concept is that brain exercises result in a higher release of neurotrophins like BDNF [41–43]. BDNF activates dendritogenesis and helps in improving cognitive function [42,43]. Practicing long-term neurobics may induce a change in brain morphology due to neuroplasticity. Studies have found that London taxi drivers have increased grey matter and larger hippocampal volume, as driving is a neurobic that impacts these brain regions [42,44]. Similarly, learning music improves verbal and working memory [41,42].
Acquiring new knowledge is beneficial for the brain, but not all types of learning can lead to the formation of new synapses. To foster the formation of new synapses, it is important to challenge the brain to coordinate and perform complex movements in conjunction with a specific task [38]. This could be acrobatic training, for example. Engaging in motor learning, such as learning a new technique in table tennis or juggling, can also lead to the formation of new synapses that help to improve that skill [39].
A study found that adult rats trained in complex acrobatic movements developed new synapses, while rats assigned to physical exercise or no activity did not [40]. The study also revealed no significant difference in the density of synapses between the group of rats that exercised and the group that did not, indicating that exercise alone may not be sufficient to promote the formation of new synapses [40].
Besides implementing healthy habits like plenty of sleep, exercise, a good diet, and a regular meditation practice, there are some exciting molecules can help us stay mentally strong by optimizing our brain chemistry.
And surprise! Methylene blue (MB) is one of them. Although we are not suggesting you change or stop any of your medications unless you speak to your healthcare provider, MB may be the answer to many mood disbalances, even showing promising early results for treating psychiatric and neurological disorders.
At Troscriptions, our products optimize health rather than treat disease. In this context, our methylene dosing was designed to leverage this magical blue compound for its energy enhancing and antioxidant properties while at the same time minimizing the risks of possible toxicity.
In this blog, we’ll discuss the why behind Tx dosing and also take a keep dive into the potential dangers of taking higher dose methylene blue, especially for longer periods of time.
