Dr. Dominic D’Agostino, Ph.D.: Effects of Ketosis + Fasting on Mitochondrial Health and Epigenetics

Dr. Dominic D’Agostino, Ph.D with Dr. Scott Sherr: Effects of Ketosis + Fasting on Mitochondrial Health and Epigenetics

Dr. D’Agostino chats with host Dr. Scott Sherr on manta rays being ketogenic, his early research in the field of oxidative stress, ketones in cancer, ketones and its effect on mitochondrial function, ketones and epigenetics, and so much more.

Who is Dr. Dominic D'Agostino? 

Dr. Dominic D’Agostino, Ph.D. He is an Associate Professor with tenure at the University of South Florida where he teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition(IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.

What did Dr. Scott discuss with Dr. Dominic D'Agostino?

00:00:22 - Introduction

00:02:12 - Manta Rays are ketogenic

00:03:54 - Is it common for fish to use ketones as fuel?

00:05:22 - How Dr. D’Agostino got into the ketogenic diet

00:08:49 - Oxidative stress

00:09:49 - Ketones in cancer

00:13:12 - The ketogenic diet

00:14:56 - The protein sparing modified ketogenic diet

00:16:24 - How Dr. D’Agostino got involved in the optimal performance world

00:19:53 - Ketones and its effects on mitochondial function

00:27:11 - Ketones and Epigenetics

00:30:43 - Dr. D’Agostino’s thoughts on ketones over the years

00:34:02 - The mechanism of a ketone induced increase in insulin

00:38:18 - Maintaining ketosis for long periods of time

00:45:07 - The Ketogenic diet and neurotransmitters

00:54:16 - Effects of long term ketogenic diets of menstrual cycle

00:56:26 - Ketonegic diet and microbiome

01:01:49 - The best way to keep your glucose from spiking

01:04:11 - Ketogenic diet and endocannabinoid system

01:07:21 - Dr. D’Agostino’s exciting project on metabolic psychiatry

Learn more about Dr. Dominic D'Agostino



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Comments (1)

  • I always learn something important when Dr. Dom speaks. I feel like I can trust what he says about keto more than a lot of others because of the high-level research he does as well as his own self-experimentation with verified lab testing. (He’s mighty easy on the eyes too 🤗) Above all else, he’s still humble and willing to admit when he finds out that he was mistaken about something – like his warning in this video about overdosing on exogenous ketones. I was just headed into that using recent purchases of ketone salts and ester so I really appreciate that warning!

    I found your podcast while searching for a new podcast with Dr. Dom. Thanks for having him on!
    I look forward to catching more good podcasts such as this on Smarter, Not Harder!


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