Learning & education
Can psychedelics be nootropics? Yes indeed! They are PONs + psychoplastogens! Let us explain...
The use of classical psychedelic substances for therapeutic purposes has surged in recent years.
Programs! Get your programs! In this article, we’re going to take a look at the default mode network (DMN), also known as the default state network + ways to modulate its activity!
Whether in the boardroom, bedroom, on the athletic pitch, hiking Everest, fluffing (Google it), or trying to finish an ultramarathon, can we all agree that performance is kind of a big deal?Let's talk Performance Optimization Nootropics (PONs)!
First-pass metabolism, otherwise known as the "first-pass effect." This phenomenon relates mainly to drugs and other supplements that are consumed orally. The concentration of a drug or supplement that we ingest is often not the amount that is eventually seen in the blood (systemic circulation).
Methylation is the addition of a methyl group (consisting of one carbon atom bonded to three hydrogen atoms) to a substrate, and it impacts physiology in a number of fundamental ways, including the regulation of gene expression (i.e., epigenetics), RNA processing, modifying heavy meals, modulating the function of an array of different proteins, and much, much more.
In this article, we will explore an important neurotransmitter in the body and brain called acetylcholine (ACh). While also functioning as a classical neuromodulator, ACh is similar to norepinephrine, serotonin, and dopamine in that it cannot cross the blood-brain barrier.