Learning & education: GABA
Agarin is chemically very similar to gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain. GABA is synthesized from glutamate by the enzyme glutamate decarboxylase with pyridoxal phosphate (vitamin B6) as a cofactor.
L-theanine (or N-ethyl-L-glutamine) is an amino acid analog structurally similar to L-glutamate, one of the primary excitatory neurotransmitters in the central nervous system (CNS).
Reducing GABA-A receptor signaling can have profound effects on the central nervous system, leading to significant physiological and neurological consequences, including increasing neuronal excitability, altered pain perception, mood changes, increased anxiety, and seizures.
How do GABA supplements exert their action? Is the observed effect merely a result of the placebo effect? Do these supplements work through peripheral mechanisms outside the brain? Or can GABA actually cross the blood-brain barrier?
The goals of this article are to explore the effect of GABA on muscle protein synthesis and evaluate its use as an ergogenic aid for the maintenance or enhancement of skeletal muscle mass to support optimal health.
GABA and gabapentin are two fundamentally different compounds that share some important similarities. The goals of this article are to provide some background on each one as well as an overview of both their shared and unique qualities.
AI-generated responses are for informational purposes only and do not constitute medical advice. Accuracy, completeness, or timeliness are not guaranteed. Use at your own risk.
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