1. SSRI and SNRI medications: Symptoms are unlikely but should be monitored closely.

2. Serotonergic pyschedelics (LSD, psilocybin). Abstain from Tro+Blue for 24 hours prior and after

3. Caution with dopaminergic drugs (Sinement for PD) as MB increases dopamine slightly, symptoms unlikely.

4. Caution with serotonergic supplementation (i.e. high dose 5HTP), symptoms unlikely

See full list linked here.

1. Pregnant or Breastfeeding
2. Hepatic or renal impairment
3. Any known sensitivity to methylene blue or thiazine dyes

1. Blue urine: Methylene Blue concentrates in the urine. This is benign side effect.
2. Headaches (typically means need to start at a lower dose)
3. Normal Biofilm disruption
4. Gastric Ulceration
5. Oxidative stress
6. G6P Deficiency and induced hemolysis (very unlikely at this dosing)
7. HTN: Some patients will have increase in their blood pressure transiently althoug those with an an inflammatory component to their HTN may see an improvement.
8. The presence of methylene blue in the blood may result in an underestimation of the oxygen saturation reading by pulse oximetry

*We recommend short-term use of Tro+ Blue due to the above under most circumstances.

1. Methylene Blue

See full information with references here (article) and here (PDR):

A. Mitochondria:

• Increases ATP production (donates electrons to complex IV on ETC)

• Increases antioxidant reserve (accepts electrons to neutralize ROS)

• Increases NAD+ production via enhanced glycolysis and NADPH oxidation.

B. Mild MAOI ➔ Increases serotonin, dopamine, and norepinephrine.

C. Benefits include enhanced energy, neuroprotection, endurance, mood boosting

Range of 25mg QOD to 200mg daily.

Consider starting at Just Blue dosing in those very sensitive examples*

*Note the above ranges are guidelines only based on research, much of it in animals, and clinical experience from practitioners on the Troscriptions team and their colleagues around the globe. Please take them as guidelines only and if you find different dosing works more optimally, please let us know at buccalup@troscriptions.com. We appreciate your feedback!

1. Polyethylene Glycol: See full article here

• Suspends active ingredients in the buccal troche for slow release

• Very low dose (< 500mg/troche)

• Not absorbed out of the GI system (fully excreted)

• Pharmaceutical grade and tested

2. Silica: Food Grade Silica. See more information here

3. Bitter Bloc: See more information here

• Non-GMO

• Preservative and Dye Free

• GRA Status

• Mushroom derived

4. Luo han: Monk Fruit

5. Stevia: Natural Sweetener

6. Peppermint