We live in a go-go-go world that glorifies constant productivity, making it harder than ever to switch off and truly relax. This relentless pace keeps the nervous system stuck in overdrive, leaving people overwhelmed, anxious, and struggling with sleep. GABA, the brain’s primary inhibitory neurotransmitter, is key to activating the body's "off switch”. Stress, toxin exposure, infections, inflammation, nutrient depletion, and more deplete GABA and increase our risk of depression, anxiety, and insomnia.
Recognizing a significant need to support the GABA system — and knowing that direct GABA supplementation shouldn’t work because it is too large a molecule to get across the blood-brain barrier (unless there is a leaky brain) — we developed Tro Calm™ and Tro Zzz™, our precision-dosed troches designed to help the body transition from "on" to "off" naturally and on demand. These relaxation and sleep solutions feature our unique Oblipair™ technology.
What is an Oblipair™ and why is it so important?
Imagine a team-up of two superstar molecules: one that steps in like a perfect substitute, binding to and activating a receptor just like your body's natural molecule would (its fancy name: an orthosteric ligand), and another that plays the role of the cool sidekick, boosting the receptor’s connection with your natural molecule by binding to a separate site on the receptor (its fancy name: a positive allosteric modulator, or PAM).
At Troscriptions®, we call this patent-pending combination an Obligate Pairing (Oblipair™) Strategy.
Most supplements, formulas, and drugs only use the sidekick — the PAM — which can deplete the body’s natural supply of GABA over time, especially drugs like alcohol and benzodiazepines. This depletion increases the risk of tolerance, withdrawal, and dependence.
The Oblipair™ solves this by pairing an orthosteric ligand (like agarin in Tro Zzz™), with a carefully selected PAM that enhances GABA activity, enhancing GABA’s natural function without the risks of tolerance, withdrawal, and dependence that comes with GABA depletion.
Troscriptions: The Oblipair™ at work
Tro Calm™
Tro Calm™ is designed for individuals struggling with anxiousness, stress, and a racing mind. Its Oblipair™ Strategy includes N-nicotinoyl-GABA, which crosses the blood-brain barrier to directly increase GABA levels in the brain. GABA then binds to its receptor, acting as both an orthosteric and endogenous ligand. This is paired with kava, CBD, and CBG, all acting as PAMs, binding to separate receptor sites on the GABA receptor. Together, these ingredients promote calmness, reduce stress, and quiet an overactive mind.
Tro Zzz™
Tro Zzz™ is a comprehensive sleep formula for those who struggle with falling asleep, staying asleep, or achieving restful sleep. Its Oblipair™ Strategy includes agarin, a long-acting compound that binds directly to the same site on the GABA receptor as GABA itself (orthosteric ligand). This is paired with honokiol, CBD, and CBN, all of which act as PAMs, enhancing GABA’s ability to promote relaxation. This carefully balanced formula supports the onset of sleep, helps maintain uninterrupted rest, and encourages deep, restorative sleep cycles.
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